In industrial synthesis, acetylene reacts with two equivalents of formaldehyde to form 1,4-butynediol. Hydrogenation of 1,4-butynediol gives 1,4-butanediol. It is also manufactured on an industrial scale from maleic anhydride in the Davy process, which is first converted to the methyl maleate ester, then hydrogenated. Other routes are from butadiene, allyl acetate and succinic acid.
A biological route to BD has been commercialized that uses a genetically modified organism.[6] The biosynthesis proceeds via 4-hydroxybutyrate.
1,4-Butanediol seems to have two types of pharmacological actions. The major psychoactive effects of 1,4-butanediol are because it is metabolized into GHB; however there is a study suggesting that 1,4-butanediol may have potential alcohol-like pharmacological effects on its own.[17] The study arrived at this conclusion based on the finding that 1,4-butanediol co-administered with ethanol led to potentiation of some of the behavioral effects of ethanol. However, potentiation of ethanol's effects may simply be caused by competition for the alcohol dehydrogenase and aldehyde dehydrogenase enzymes with co-administered 1,4-butanediol. The shared metabolic rate-limiting steps thus leads to slowed metabolism and clearance for both compounds including ethanol's known toxic metabolite acetaldehyde.
1,4-butanediol, 110-63-4, cas 110-63-4
110-63-4, 1 4 Butanediol, cas 110-63-4, BDO, BDO supplier, AUS Butanediol,
Australia 14 butanediol,GBL, Gamma-butyrolactone, 96-48-0,7331-52-4
1,4-Butanediol 110-63-4, Density 1.0±0.1 g/cm3
1,4-Butanediol 110-63-4, Boiling Point 228.0±0.0 °C at 760 mmHg
1,4-Butanediol 110-63-4, Melting Point 20 °C
1,4-Butanediol 110-63-4, Molecular Formula C4H10O2
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